Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
USERS' SCORE
Moderately Good
Based on 64 Reviews
7.7
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
9
We explored a creative approach to treat rheumatoid arthritis, focusing on a new delivery method for tacrolimus using hyaluronic acid-coated nanogels.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
9
Elastic skin boost
9 people found this helpful
Following my beautician's advice, I began a regimen of collagen and hyaluronic acid. My skin was extremely dry from hard water, but now it feels smooth and elastic. After initially taking a break, I resumed with great results - my skin has improved significantly.
Read More
9
Significant improvement
8 people found this helpful
This product was highly recommended by my nutritionist. I have been taking it recently alongside other medications, feeling significant improvements. I will order more and continue under my doctor's guidance, who recommended taking it in courses. The parcel was well packed and delivered on time. Highly recommend!
Read More
8
Skin firmness improved
8 people found this helpful
This product is excellent! After using it for about two weeks, I felt my skin had become firmer and better moisturised. Within a week, my forehead wrinkles vanished. The formula contains collagen, and I will definitely reorder.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
- All Researches
9.5
We explored a novel injectable hydrogel designed to treat rheumatoid arthritis, which often causes joint lubrication issues and cartilage damage. This hydrogel incorporates modified hyaluronic acid and nanozymes that work together to reduce inflammation and promote cartilage repair.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
Read More
9
We aimed to tackle the side effects of long-term use of tofacitinib, a well-known treatment for rheumatoid arthritis. By creating hyaluronic-acid-coated transethosomes, we delivered tofacitinib directly to affected areas, enhancing efficacy while reducing side effects. Our results showed significant anti-inflammatory effects, with marked reductions in inflammatory markers in treated rats compared to conventional delivery methods. This suggests that our targeted approach may offer a promising alternative for managing rheumatoid arthritis with fewer systemic impacts.
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9
Innovative dual-drug treatment examined
We explored the potential of hyalurosomes that combine dexamethasone and luteolin as a treatment for rheumatoid arthritis. In a study using a rat model, we observed significant reductions in inflammatory markers like TNF-α and MDA, suggesting these dual drug-loaded hyalurosomes could effectively decrease inflammation and swelling in joints.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Read More
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 64 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Elastic skin boost
9 people found this helpful
Following my beautician's advice, I began a regimen of collagen and hyaluronic acid. My skin was extremely dry from hard water, but now it feels smooth and elastic. After initially taking a break, I resumed with great results - my skin has improved significantly.
Read More
9
Significant improvement
8 people found this helpful
This product was highly recommended by my nutritionist. I have been taking it recently alongside other medications, feeling significant improvements. I will order more and continue under my doctor's guidance, who recommended taking it in courses. The parcel was well packed and delivered on time. Highly recommend!
Read More
8
Skin firmness improved
8 people found this helpful
This product is excellent! After using it for about two weeks, I felt my skin had become firmer and better moisturised. Within a week, my forehead wrinkles vanished. The formula contains collagen, and I will definitely reorder.
Read More
9
Knee pain reduced
5 people found this helpful
My knee pain was persistent until I began taking two tablets daily. Remarkably, within four days, my knee pain lessened significantly, allowing me to travel without discomfort. I am genuinely surprised by its effectiveness and plan to order more for my family to try.
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9
Knee pain relief
5 people found this helpful
It worked! I took this hyaluronic acid with chondroitin after collagen types 1 and 3 as well as coenzyme Q10. To my surprise, the knee that had been hurting for nearly a year no longer aches. There was a sensation of puffiness that has disappeared. It has been less than 10 days of taking it. I’ll order another jar.
Read More
Frequently Asked Questions
9
Knee pain reduced
5 people found this helpful
My knee pain was persistent until I began taking two tablets daily. Remarkably, within four days, my knee pain lessened significantly, allowing me to travel without discomfort. I am genuinely surprised by its effectiveness and plan to order more for my family to try.
8
Skin firmness improved
8 people found this helpful
This product is excellent! After using it for about two weeks, I felt my skin had become firmer and better moisturised. Within a week, my forehead wrinkles vanished. The formula contains collagen, and I will definitely reorder.
7.5
Joint and skin relief
158 people found this helpful
I received the product promptly and it was well-packaged. After a week of use, I've noticed positive changes in my joints and skin. I've ordered another batch and plan to continue using hyaluronic acid for a long duration due to its exceptional quality and effectiveness.
0
No effect observed
2 people found this helpful
I was really disappointed. I’ve been using collagen for a long time and hyaluronic acid intermittently, so I ordered Doctor's Best, expecting great synergy between collagen, hyaluronic acid, and Chondroitin. However, it had no effect at all! I have been taking it for 2 months with no benefits, which is disappointing for a recognized brand.
9
Helped knee issues
5 people found this helpful
Hyaluronic acid with chondroitin sulfate has been a great help! After consuming the entire jar, my dry throat resolved (which I had struggled with), and my knees have stopped crunching when I move. They have also ceased to hurt. I plan to continue for three months as recommended by the manufacturer. Since the results are positive, I will reorder. Highly recommended for others with these issues!
9
Knee pain relief
5 people found this helpful
It worked! I took this hyaluronic acid with chondroitin after collagen types 1 and 3 as well as coenzyme Q10. To my surprise, the knee that had been hurting for nearly a year no longer aches. There was a sensation of puffiness that has disappeared. It has been less than 10 days of taking it. I’ll order another jar.
9
Joint pain relief
3 people found this helpful
My mum ordered this to relieve her knee pain; she frequently uses ointments and wears knee pads. After a month of use, she no longer requires the ointment, and the crunching in her joints has vanished.
9
Significant changes
3 people found this helpful
This miracle supplement truly works! My mom ordered it after reading good reviews. Within three days, her skin appeared more toned and tighter, and she experienced fewer joint issues. If this review was helpful, please click "YES"!
9
Elastic skin boost
9 people found this helpful
Following my beautician's advice, I began a regimen of collagen and hyaluronic acid. My skin was extremely dry from hard water, but now it feels smooth and elastic. After initially taking a break, I resumed with great results - my skin has improved significantly.
7.5
Skin condition improved
14 people found this helpful
I consistently order hyaluronic acid from this manufacturer and remain impressed with the results. My skin, hair, nails, and joints have all benefitted. Since turning fifty, using it alongside coenzyme Q10 and collagen has fostered healthier skin and eliminated joint crunching.
9
Joint pain resolved
1 people found this helpful
I am very happy! I took this for my joints. The pain in my elbow and wrist has completely vanished in about two months! I've also been taking it alongside collagen types 1 and 3 and plan to continue for at least three more months.
9
Significant improvement
8 people found this helpful
This product was highly recommended by my nutritionist. I have been taking it recently alongside other medications, feeling significant improvements. I will order more and continue under my doctor's guidance, who recommended taking it in courses. The parcel was well packed and delivered on time. Highly recommend!
8
Novel injectable hydrogel for RA
We explored a new injectable treatment for rheumatoid arthritis (RA) using a specialized hydrogel made from hyaluronic acid and chitosan. This platform targets inflammation by efficiently releasing the drug methotrexate only in areas of active swelling.
In our study, we observed that this treatment not only reduced harmful reactive oxygen species but also promoted healing in the joint environment. However, while there were positive indicators, the results highlighted a need for further research to confirm its overall effectiveness in long-term RA management.
In our study, we observed that this treatment not only reduced harmful reactive oxygen species but also promoted healing in the joint environment. However, while there were positive indicators, the results highlighted a need for further research to confirm its overall effectiveness in long-term RA management.
8
Hyaluronic acid benefits uveitis treatment
We investigated how hyaluronic acid-curcumin nanoparticles (HA-CUR NPs) could help prevent autoimmune uveitis progression. Our research points to these nanoparticles having impressive antioxidant properties, helping counter inflammation and oxidative stress that drive uveitis. They appear to target specific receptors and activate protective cellular pathways, leading to reduced damage to the retina and enhanced blood flow in ocular areas. This suggests that HA-CUR NPs could be a promising new option for treating autoimmune-related eye conditions, although traditional treatments have had serious side effects.
9
We explored a creative approach to treat rheumatoid arthritis, focusing on a new delivery method for tacrolimus using hyaluronic acid-coated nanogels.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
9
We aimed to tackle the complex challenges of rheumatoid arthritis (RA) by employing innovative nanoparticles that harness the power of hyaluronic acid.
In our research, these specialized nanoparticles demonstrated the ability to deliver the anti-inflammatory drug methotrexate directly to inflamed joints, effectively neutralizing harmful nitric oxide and pro-inflammatory signals.
In tests using a mouse model, we observed a notable reduction in RA symptoms such as joint swelling and cartilage damage, revealing a promising avenue for more effective treatment options.
In our research, these specialized nanoparticles demonstrated the ability to deliver the anti-inflammatory drug methotrexate directly to inflamed joints, effectively neutralizing harmful nitric oxide and pro-inflammatory signals.
In tests using a mouse model, we observed a notable reduction in RA symptoms such as joint swelling and cartilage damage, revealing a promising avenue for more effective treatment options.
References
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. 10.1038/s41467-025-58059-z
- Tang W, Huang X, Yi YD, Cao F, Deng M, et al. Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway. J Nanobiotechnology. 2025;23:89. 10.1186/s12951-024-03082-3
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. 10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. 10.1016/j.colsurfb.2025.114497
- Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. 10.1016/j.ijpharm.2024.125073
- Liu X, Chen X, Fei Y, Zhang J, Yue O, et al. Locally Injectable, ROS-Scavenging, and ROS-/pH-Responsive Polymeric-Micelles-Embedded Hydrogels for Precise Minimally Invasive and Long-Lasting Rheumatoid Therapy. Adv Healthc Mater. 2025;14:e2403579. 10.1002/adhm.202403579
- Papp FR, Katko M, Csiki R, Galgoczi E, Molnar Z, et al. Characteristics of Hyaluronan Metabolism During Myofibroblast Differentiation in Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2024;65:13. 10.1167/iovs.65.13.13
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiO₂ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. 10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. 10.1186/s12951-024-02784-y
- Xu M, Fu T, Zhang C, An Z, Yan J, et al. Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy. J Control Release. 2024;375:60. 10.1016/j.jconrel.2024.08.046
- Deng YS, Shen XY, Long MT, Zheng H, Li B, et al. [MMPs/pH synergically responsive XTS-Prussian blue nanoparticles inhibiting proliferation and migration of RAFLS assisted with laser irradiation]. Zhongguo Zhong Yao Za Zhi. 2024;49:2906. 10.19540/j.cnki.cjcmm.20240304.303
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. 10.1016/j.ijpharm.2024.124449
- Liu X, Zhang Q, Cao Y, Hussain Z, Xu M, et al. An Injectable Hydrogel Composing Anti-Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis. Adv Healthc Mater. 2024;13:e2304668. 10.1002/adhm.202304668
- Zhu H, Huang D, Wang J, Zhao Y, Sun L. Viral Mimicking Polyplexes as Hierarchical Unpacking Vectors for Rheumatoid Arthritis Treatment. Adv Sci (Weinh). 2024;11:e2402888. 10.1002/advs.202402888
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. 10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. 10.1021/acs.biomac.4c00556
